On Run's House, Rev Run (Joey Simmons) of Run DMC, must balance releasing his first ever solo album, Distortion, while raising five spirited children ages 9-21. The series captures the real-life drama and hysterical antics of the Simmons family which is comprised of: Run's wife Justine, a former rapper/singer and loving wife and mother; Vanessa, 22, a Ford model, former Miss Teen New York and aspiring actress; Angela, 18, a straight A student and aspiring fashion designer; JoJo, 16, a talented rapper who loves music and girls; Diggy, 10, star of the basketball team and an aspiring rapper; and Russell, Jr., 9, the mischievous little brother. And just down the street from Run's home live his brother and sister-in-law Russell and Kimora Simmons who spend time with the family.